Synthesis of an Active Pharmaceutical Ingredient, Aspirin ( Including Raw Materials and Product Purity Checks )

Date: 6/3/2012 Title : Synthesis of an straightaway Pharmaceutical Ingredient, Aspirin ( Including Raw Materials and Product Purity Checks ) pattern: Class: Lab partners: Aim: The aim of this experiment is to fig up and recrystallise Aspirin, determine the percentage supply by big bucks of intersection, preform a test to check for phenols, and characterise it by its run point. The following is the reactions scheme: Method: -[Lab Manual Pages 3, 4 & 5]- Results and Calculations: complexSalicylic back breakerAcetic AnhydrideAspirin AppearanceWhite PowderClear, pallid meltedWhite Crystals Molar Mass (g/ mole)138g/mol102g/mol180g/mol Density if liquid (g/cm3)1.08g/cm3 Weight use (g)2.868g5.4gN/A Moles used (mol)0.0207mol0.0529molN/A contain Reagent ??N/A theory-based regress of Products in molesN/AN/A0.0207M a priori Yield of Product in Grams N/AN/A3.726g Calculations from table ^ : Moles of Salicylic Acid : Moles= Mass X Mr => M = 2.868 X 138 = 0.0207moles Moles of Acetic Anhydride : M = 5.4 X 102 = 0.0529moles Theoretical Yield in moles : moles of limiting reagent = 0.0207moles Theoretical Yield in Grams : Moles of limiting reagent X Mr of Product : = 0.0207mol X 180g/mol = 3.

726g Melting Points CompoundSalicylic dot (raw material)Recrystallised Aspirin Expected MP cherish157-161oC138-140oC Actual MP Value158-160oC137-139oC Percentage yield: Percentage yield = 2.214/3.72 ? 100 = 59.52% => 60% Test for phenols: SamplesCrude AspirinRecrystallised AspirinSalicylic Acid Colour convey of Samples + 1cmoC methanol Yellowish Yellowish Purpl e InferencePhenol non presentPhenol not pr! esentPhenol register Post- functional Questions : Q1 What did your melting point indicate about the accolade of your product? Explain your answer. ¬The melting point indicated that the prove obtained was pure. If a sample differs by 1-2 oC it is...If you want to get a just essay, invest it on our website: OrderEssay.net

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